Vol. 35 No. 3 (2018): June
Short Communication

Susceptibility to first-generation Cephalosporins in Enterobacteriaceae isolated from urine culture according to CLSI and EUCAST breakpoints

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  • Valerie Corvalán,
  • Beatrice Hervé,
  • Camila Sanhueza,
  • Nicolás Martínez,
  • Maria Almonacid,
  • Sebastián De La Fuente

Published 2018-07-16

Keywords

How to Cite

1.
Corvalán V, Hervé B, Sanhueza C, Martínez N, Almonacid M, De La Fuente S. Susceptibility to first-generation Cephalosporins in Enterobacteriaceae isolated from urine culture according to CLSI and EUCAST breakpoints. Rev. Chilena. Infectol. [Internet]. 2018 Jul. 16 [cited 2026 Jan. 23];35(3). Available from: https://www.revinf.cl/index.php/revinf/article/view/127

Copyright (c) 2018 Valerie Corvalán, Beatrice Hervé, Camila Sanhueza, Nicolás Martínez, Maria Almonacid, Sebastián De La Fuente

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Currently, the use of cefazolin is recommended to determine the susceptibility to first-generation oral cephalosporins in strains of enterobacteria in uncomplicated UTI. We determined susceptibility differences to oral cephalosporins in urinary strains according to cefazolin or cefalotin breakpoints and the correlation of susceptibility between cefazolin and cefadroxil. We studied 52 strains with cefalotin and cefazolin by disk-diffusion and MIC (Kirby-Bauer and Vitek XL) and a subgroup by disk-diffusion for cefadroxil. Agreement among different methods was 100% for K. pneumoniae and Proteus spp. In Escherichia coli, agreement for Vitek and disk-diffusion were 0 and 50% respectively. Susceptibility to first generation cephalosporins in E. coli should be determined with cefazolin. Agreement between cefazolin and cefadroxil suggests that cefazolin could also predict the susceptibility of cefadroxil.
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