Vol. 41 No. 1 (2024): Febrero
Sexually Transmitted Infections

Distribution of high-risk human papillomavirus genotypes in women and men attended in a private healthcare network in the Metropolitan Region, Chile.

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  • Cecilia Veronica Tapia Paredes,
  • Marcia Campos,
  • Nadia Pozas,
  • Antonia Sardá,
  • Kenneth Walker
Cecilia Veronica Tapia Paredes
Laboratorio Microbiología y Biología Molecular Clínica Dávila
Bio
Marcia Campos
Clínica Dávila, Santiago
Nadia Pozas
Clínica Dávila
Antonia Sardá
Laboratorio de especialidad Omesa-Dávila
Kenneth Walker
Alatheia
Revista Chilena de Infectologia - febrero 2024
DOI: https://doi.org/10.4067/s0716-10182024000100020

Published 2024-02-02

Keywords

How to Cite

1.
Tapia Paredes CV, Campos M, Pozas N, Sardá A, Walker K. Distribution of high-risk human papillomavirus genotypes in women and men attended in a private healthcare network in the Metropolitan Region, Chile. Rev. Chilena. Infectol. [Internet]. 2024 Feb. 2 [cited 2025 Nov. 27];41(1). Available from: https://www.revinf.cl/index.php/revinf/article/view/2024000100020

Copyright (c) 2024 Cecilia Veronica Tapia Paredes, Marcia Campos, Nadia Pozas, Antonia Sardá, Kenneth Walker

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: Persistent infection by high-risk human papillomavirus (HR-HPV) genotypes is the main cause of cervical cancer worldwide. Genotypes 16 and 18 are associated with progression to cervical cancer, however other genotypes also present high oncogenic risk. There is little evidence regarding the distribution of HR-HPV genotypes in the national population, being an issue that should be addressed in the context of a growing increase in immigration and implementation of the immunization program in Chile since 2015. Aim: To show the distribution of HR-HPV genotypes detected in women and men, attended at the private care network of Clínica Dávila, Santiago City, between 2014 and 2021. Methods: Genital and anal samples from 3642 patients were studied, including both sexes. Genotyping was performed by real-time polymerase chain reaction (PCR) (HPV AnyplexTM II HPV28 detection, Seegene, Korea). Results: The global distribution of genotypes in women (percentage) was: 16 (14.34%) - 31 (6.20%) - 39 (5.94%) - 58 (5.94%) - 51 (5.68%) - 53 (5.64%) - 52 (5.30% ) - 56 (5.27%) - 68 (5.19%) - 66 (4.97%) - 18 (3.36%) - 59 (3.29%) - 73 (2.80%) - 35 (2.54%) - 45 (2.13%) - 33 (1.53%) - 82 (1.38%) - 26 (0.49%) and 69 (0.41%). In men was: 16 (8.52%) - 58 (4.39%) - 51 (8.44%) - 26 (0.42%) - 18 (3.21%) - 52 (4.47%) - 39 (5.40%) - 53 (4.56%), 33 (1.69%) - 35 (2.03%) - 73 (2.19%) - 69 (0.59%) - 45 (2.11%) - 59 (4.22%) - 68 (3.04%) - 66 (5.06%) - 31 (4.64%) - 56 (4 .81%) and 82 (1.10%). Conclusions: The distribution of HPV genotypes was consistent with previous national studies. A tendency to reduce genotype 16 over the years was observed, which could be related to the vaccination, implemented in recent years in Chile. It is remarkable that other HR-HPV genotypes had a high frequency in the population studied, so it would be advisable to evaluate an expanded screening for HR-HPV genotypes to assess the oncogenic risk, for diagnostic and therapeutic purposes.

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