Trends in therapeutic vancomycin monitoring in Chile

Abstract

Introduction: The use of vancomycin requires therapeutic drug monitoring (TDM) to ensure its effectiveness and avoid nephrotoxicity. The latest vancomycin therapeutic drug monitoring guidelines switched from targeting trough levels to AUC24/MIC-based dosing. Objective: To investigate the trends in vancomycin TDM in Chile, including the implementation status of AUC24/MIC-based TDM. Methods: A nationwide survey was conducted across Chilean hospitals using an online questionnaire validated for this study. Results: A total of 51 questionnaires were completed. Vancomycin TDM was implemented in almost all hospitals (94,1%, n=48), being performed in adult patients (91,7%, n=44) and starting 24-48 h after first dose of vancomycin (64,6%, n=31). Pharmacists conducted TDM in Chile and in just 7 hospitals (14,5%) were formally specialized. Most hospitals performed AUC24/MIC-based vancomycin TDM (81,3%, n=39). Conclusion: AUC24/MIC-based vancomycin TDM was widely implemented among surveyed hospitals. Our study indicates a high compliance of international guidelines in Chile and underscores the need for standardized protocols and professional certifications.