Vol. 36 No. 2 (2019): April
Clinical Case

Adult T cell lymphoblastic leukemia/lymphoma by HTLV-1 in a young woman

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  • Sandra Delgado,
  • Eduardo Gotuzzo
Sandra Delgado
Universidad Peruana Cayetano
Eduardo Gotuzzo
Universidad Peruana Cayetano

Published 2019-04-30

Keywords

How to Cite

1.
Delgado S, Gotuzzo E. Adult T cell lymphoblastic leukemia/lymphoma by HTLV-1 in a young woman. Rev. Chilena. Infectol. [Internet]. 2019 Apr. 30 [cited 2025 Nov. 22];36(2). Available from: https://www.revinf.cl/index.php/revinf/article/view/424

Copyright (c) 2019 Sandra Delgado, Eduardo Gotuzzo

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Adult T cell lymphocyte leukemia/lymphoma (ATLL) is a subtype of T-cell lymphoma caused by infection of the human T-cell lymphotropic virus type 1 (HTLV-1); which generates a pro-viral integration into the host DNA, resulting in a clonal expansion of T lymphocytes. We present the case of a 20-year-old woman who developed multiple lymphadenopathies, hepatosplenomegaly and fever, serum positivity for HTLV-1 and proviral integration in the host DNA, demonstrated by polymerase chain reaction (PCR). Immunohistochemistry of lymphoid node was positive to CD4+ and CD8+ T cells. ATLL has been described in all HTLV-1 endemic areas, however, there are differences in the mean age of its presentation in such areas: 40 to 50 years in South America, 60 years in Japan. We showed one of few reported cases of the lymphoma type of ATLL in young adults.
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